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何林洪

作者:pmo4b69bd   来源:药学院   校对:药学院   审核:李福森   发布时间:2022-10-13

    药学副教授,硕士研究生导师,理学博士,天然药物化学教研室教师,广西药学会会员。承担《天然药物化学》、《中药化学》和《波谱分析》课程的教学工作。长期从事免疫系统疾病和肿瘤相关的小分子靶向药物研究,具有较为系统的小分子药物设计、合成及药效学评价相关知识及研究经验。

代表性课题(主持)

1. 广西自然科学基金面上项目,2022JJA140155,安全高效靶向类风湿关节炎治疗的JAK3/iNOS双重共价抑制剂的设计与合成研究,2023-04至2026-03,10万元,在研。

2. 国家自然科学基金地区项目,82260673,安全高效靶向类风湿关节炎治疗的JAK3/Bmx双重共价抑制剂的设计与合成研究,2023-01至2026-12,33万,在研

3. 广西自然科学基金青年基金,2020JJB140210、结构修饰改善难溶性JAK3共价抑制剂T29的生物利用度及其对类风湿关节炎的治疗研究、2021/04-2024/03、8万元、在研

4. 国家自然科学基金青年项目,81803350,靶向耐药肺癌的高选择性共价Bmx抑制剂的设计、合成及其生物活性研究,2019-01至2021-12,21万,结题

5. 广西医科大学青年科学基金,GXMUYSF201732,具有抗耐药型非小细胞肺癌的高选择性 Bmx 抑制剂的设计和合成研究, 2019-01至2020-12,1.5万元,结题

6. 广西医科大学教师教学能力发展项目2020JFA34虚实结合的波谱解析课程学习,2020-062021-06,0.3万元,结题。

代表性论文(第/共同第一作者通讯/共同通讯作者)

1. Jin Wang, Yuxi Gu, Yuchong Zhang, Shuai Chen, Li Li, Zilong Liao, Xiaoxue Shan, Linhong He#, Jinying Chen#. Toxigenic potential analysis and fumigation treatment of three Fusarium spp. Strains isolated from Fusarium head blight of wheat. Food Science and Technology. 2022, 42, e53822.

2. Jinying Chen#, Zitai Sang, Youjun Jiang, Chao Yang, Linhong He*.Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer.Chemical Biology & Drug Design. 2019, 93:232–241.

3. 曹思思, 张洁, 曾宪霞, 黄怀征, 岳晓阳, 何林洪#. Btk /JAK3 双靶点共价抑制剂的设计、 合成及其活性研究 [J]. 化学试剂, 2021, 43(1) : 22-27.

4. 黄怀征, 姚华良, 张洁, 曾宪霞,覃廷胜,梁倩,曹思思,何林洪#.EGFR( T790M) 抑制剂的设计、合成及活性评价 [J]. 化学试剂, 2022, 44(1) : 39-45.

5. 姚华良, 曾宪霞, 张洁, 黄怀征,何林洪#. 酪氨酸激酶2抑制剂的研究进展 [J]. 化学试剂, 2023, 45(2).

6. Linhong He#, Heying Pei#, Chufeng Zhang#, Mingfeng Shao, Dan Li, Mingli Tang, Taijing Wang, Xiaoxin Chen, Mingli Xiang, Lijuan Chen*. Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis. European Journal of Medicinal Chemistry, 2018, 145: 96-112.

7. Linhong He#, Mingfeng Shao#, Taijin Wang, Tingxuan Lan, Chufeng Zhang, Lijuan Chen*.Design, synthesis and SAR study of highly potent, selective, irreversible covalent JAK3 inhibitors. Molecular Diversity, 2018, 22,343-358.

8. Linhong He#, Da Li#, Chufeng Zhang, Peng Bai, Lijuan Chen*,Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC, Bioorganic & Medicinal Chemistry Letters, 2017, 27, 4171-4175.

9. Linhong He#, Heying Pei#, Tingxuan Lan, Minghai Tang, Chufeng Zhang, and Lijuan Chen*, Design and synthesis of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis, Archiv der Pharmazie, 2017, 350, e1700194.

10. Linhong He#, Heying Pei#, Liang Ma#, Yuzhi Pu, Jinying Chen , Zhuowei Liu , Yan Ran , Lei Lei , Suhong Fu , Minghai Tang , Aihua Peng , Chaofeng Long ,Lijuan Chen*, Synthesis and lipid-lowering evaluation of 3-methyl-1H-purine-2,6-dione derivatives as potent and orally available anti-obesity agents, European Journal of Medicinal Chemistry, 2014, 87, 595-610.

11. Heying Pei#, Linhong He#, Mingfeng Shao, Zhuang Yang, Yan Ran, Dan Li, Yuanyuan Zhou, Minghai Tang, Taijin Wang, Yanqiu Gong, Xiaoxin Chen, Shengyong Yang, Mingli Xiang, Lijuan Chen*, Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis. Scientific Reports, 2018, 8, 5273.

12. Mingfeng Shao#, Linhong He#, Li Zheng, Lingxiao Huang, Yuanyuan Zhou, Taijing Wang, Yong Chen, Mingsheng Shen, Fang Wang, Zhuang Yang, Lijuan Chen*, Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors, Bioorganic & Medicinal Chemistry Letters, 2017, 27, 4051–4055.

13. Jinying Chen*, Linhong He#, Tao Yang, Scale-up Purification for Rutin Hyrdrolysates by High-performance Counter-current Chromatography Coupled with Semi-preparative High-performance Liquid Chromatography, Separation Science and Technology, 2016, 51, 1523-1530.

14. 何林洪#,许崇摇,焦杨,康亮,周春艳,马思文. 临床药学专业人文课程设置需求调研. 药学教育, 2019, 35(2): 71-74.

15. 何林洪#,科研创新型药学人才培养模式下的波谱解析课程教学改革. 中国科技经济新闻数据库 教育, 2022, 6: 171-174.

16. 何林洪#,科研创新型药学人才培养模式下的波谱解析课程教学改革. 中国科技经济新闻数据库 教育, 2022, 6: 171-174.

专利

1. 何林洪,姚华良,黄怀征。1,3,5-三嗪-2-胺-4,6-取代衍生物或其药学上可接受的盐和用途,专利号:ZL202110197192.X(中国,发明专利)。

2. 何林洪,姚华良,黄怀征。含氮杂环衍生物或其药学上可接受的盐和用途,专利号:ZL202110361324.8(中国,发明专利)。


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