作者:pmo4b69bd 来源:药学院 校对:张晓萍 审核:李福森 发布时间:2024-09-25
一、个人简介
卢覃培,理学博士,硕士生导师,天然药物化学教研室教师,目前担任中华中医药学会中药基础理论分会第四届青年委员,中国民族医药学会方药量效研究分会理事,中国抗生素杂志第二届青年编辑委员会青年编委,近年来主持国家自然科学基金1项,广西自然科学基金1项。以第一作者或者共同第一作者在Mar. Drugs、Antibiotics、Chem. Pharm. Bull.、Nat. Prod. Res.等SCI期刊发表研究性学术论文9篇,中文核心1篇,参与发表论文10余篇。
二、研究方向
(1)特境微生物资源勘探、新型抗生素的发现及发现策略;
(2)中药民族药药效物质基础研究;
(3)天然活性成分的提取分离新技术与新方法;
三、代表性科研项目(主持)
(1)国家自然科学基金委员会,地区科学基金项目,82360696,基于“活性-代谢组-基因组-SMART”整合策略发掘老鼠簕内生放线菌新型先导化合物,2024-01至2027-12,32万元,在研。
(2)广西壮族自治区科学技术厅,广西自然科学基金青年项目,2023GXNSFBA026240,药用红树植物老鼠簕内生放线菌资源勘探及其活性新型分子的高效发现,2023-06至2026-05,8万元,在研。
(3)北京协和医学院,研究生创新基金项目,2018-1007-16,基于质谱-分子网络技术快速排重及发现新抗生素,3万元,2018-09至2020-07,结题。
四、代表性研究论文
(1)Lu Qinpei†, Wu Gang†, Hao Xiaomeng, Hu Xinxin, Cai Hao, Liu Xiujun, You Xuefu, Guo Hongwei*, and Sun Chenghang*. Isolation, Structure Elucidation, and First Total Synthesis of Quinomycins K and L, Two New Octadepsipeptides from the Maowei Sea Mangrove-Derived Streptomyces sp. B475. Marine Drugs, 2023, 21(3): 143.
(2)Lu Qinpei†, Huang Yongmei†, Liu Shaowei, Wu Gang, Yang Qin, Liu Lifang, Zhang Haitao, Qi Yi, Wang Ting, Jiang Zhongke, Li Junjie, Cai Hao, Liu Xiujun, Luo Hui*, Sun Chenghang*. Metabolomics Tools Assisting Classic Screening Methods in Discovering New Antibiotics from Mangrove Actinomycetia in Leizhou Peninsula. Marine Drugs, 2021, 19(12): 688.
(3)Lu Qinpei†, Ye Jingjing†, Huang Yongmei, Liu Di, Liu Lifang, Dong Kun, Razumova Elizaveta A., Osterman Ilya A., Sergiev Petr V., Dontsova Olga A., Jia Shuhan, Huang Dalin*, Sun Chenghang*. Exploitation of Potentially New Antibiotics from Mangrove Actinobacteria in Maowei Sea by Combination of Multiple Discovery Strategies. Antibiotics, 2019, 8(4): 236.
(4)Cui Dianxin, Luo Zhuo, Liu Xi, Chen Xin, Zhang Qiuping, Yang Xin, Lu Qinpei*, Su Zhiheng*, Guo Hongwei*. Combination of metabolomics and network pharmacology analysis to decipher the mechanisms of total flavonoids of Litchi seed against prostate cancer, Journal of Pharmacy and Pharmacology, 2023, 75(7): 951–968.
(5)Chen Xin†, Luo Zhuo†, Liu Xi†, Li Xiaolan, Li Qiaofeng, Zhang Weiquan, Liu Ying, Cheng Zhiping, Yang Xin, Liu Yanying, Jin Ronghua, Zhu Dan, Wang Fengmao, Lu Qinpei*, Su Zhiheng*, Guo Hongwei*. Marsdenia tenacissima (Roxb.) Moon injection exerts a potential anti-tumor effect in prostate cancer through inhibiting ErbB2-GSK3β-HIF1α signaling axis. Journal of Ethnopharmacology, 2022, 295: 115381.
(6)Xue Wei†, Hao Jie†, Zhang Qiuping†, Jin Ronghua, Luo Zhuo, Yang Xin, Liu Yanying, Lu Qinpei*, Ouyang Yiqiang*, Guo Hongwei*. Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6. The Journal of Pharmacology and Experimental Therapeutic. 2023, 384(2): 254-264.
(7)卢覃培, 刘少伟, 胡辛欣, 游学甫, 孙承航*. 塔克拉玛干沙漠来源链霉菌Streptomyces sp. 90次级代谢产物的研究. 中国抗生素杂志, 2022, 47(07): 654-660.
(8)Lu Qinpei, Wang Junsong, Luo Jun, Wang Xiaobing, Shan Siming, Kong Lingyi*. A new acorane sesquiterpene from the aerial parts of Psychotria yunnanensis. Natural Product Research, 2014, 28(20): 1659-1663.
(9)Lu Qinpei, Wang Junsong, Kong Lingyi*. Chemical constituents from Psychotria yunnanensis and its chemotaxonomic study. Biochemical Systematics and Ecology, 2014, 52: 20-22.
(10)Li Yi†, Lu Qinpei†, Luo Jun, Wang Junsong, Wang Xiaobing, Zhu Mengdi, Kong Lingyi*. Limonoids from the Stem Bark of Khaya senegalensis. Chemical and Pharmaceutical Bulletin, 2015, 63(4): 305-310.
五、联系方式
1.联系电话:0771-5360143
2.电子邮箱:qinpei89@hotmail.com
3.通讯地址:南宁市双拥路22号药基楼